Associate Professor David Harrich has been researching HIV for thirty years, since starting as a research assistant at the University of California, Los Angeles (UCLA) in the early 1980s when the first cases of HIV/AIDS emerged.
“I’ve come close to giving up in the past. But today I’m so encouraged. I feel very fortunate because not a lot of scientists are able to stay in the same game long enough to see these sorts of developments. It involves perseverance, dedication and, of course, sustained research funding.
After years of research, he has had a breakthrough. Associate Professor Harrich has determined how to modify a protein in HIV, so that it instead provides strong, lasting protection from infection.
“This is like fighting fire with fire,” Associate Professor Harrich said.
“If this research continues down its strong path, and bear in mind there are a many hurdles to clear, we’re looking at a cure for AIDS.”
Associate Professor Harrich runs the only research laboratory and containment facilities in Queensland working with the HIV virus, QIMR’s Molecular Virology Laboratory at the Queensland Institute of Medical Research in Brisbane.
He invented the Nullbasic protein by mutating an existing HIV protein. Nullbasic has shown remarkable abilities to stop the virus replicating in a lab environment. Animal trials are due to start this year.
“I have never seen anything like it. The modified protein works every time,” Assoc Prof Harrich said.
“You would still be infected with HIV, it’s not a cure for the virus. But the virus would stay latent, it wouldn’t wake up, so it wouldn’t develop into AIDS. With a treatment like this, you would maintain a healthy immune system.”
The successful development of this type of one-off treatment would also have economic implications. HIV patients currently take a regime of drugs for the rest of their lives, which can be a significant financial burden.
This research is published in the current issue of Human Gene Therapy and can be found online at http://www.ncbi.nlm.nih.gov/pubmed/23298160